Year 2023 / Volume 115 / Number 8
Editorial
Biostatistics for gastroenterologists. Part II ̶ Rethinking sample size

411-413

DOI: 10.17235/reed.2023.9784/2023

Elena Stallings,

Abstract
Sample size determination is a critical aspect of medical studies, influencing the reliability and generalizability of research findings. This article explores the importance of sample size in both basic and clinical research. The considerations for sample size differ based on the type of research, whether it is involving humans, animals, or cells. In basic research, a larger sample size is necessary to ensure statistical power and reliable results, enhancing the precision and generalizability of findings. In clinical research, determining an appropriate sample size is crucial for obtaining valid and clinically relevant results, ensuring sufficient statistical power to detect differences between treatment groups or validate intervention efficacy. Reporting sample size calculations accurately and complying with reporting guidelines, such as the CONSORT Statement, is essential for transparent and comprehensive research publications. Consulting a statistician is highly recommended to ensure appropriate sample size determination, enhance scientific rigor, and obtain reliable and clinically relevant findings in medical research.
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07/08/2023 2:56:32
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References
1. Zlowodzki M, Bhandari M. Outcome measures and implications for sample-size calculations. J Bone Joint Surg Am. 2009 May;91 Suppl 3:35-40. doi: 10.2106/JBJS.H.01602. PMID: 19411498.
2. Bujang MA. A Step-by-Step Process on Sample Size Determination for Medical Research. Malays J Med Sci. 2021 Apr;28(2):15-27. doi: 10.21315/mjms2021.28.2.2. Epub 2021 Apr 21. PMID: 33958957; PMCID: PMC8075593.
3. Serdar CC, Cihan M, Yücel D, Serdar MA. Sample size, power and effect size revisited: simplified and practical approaches in pre-clinical, clinical and laboratory studies. Biochem Med (Zagreb). 2021 Feb 15;31(1):010502. doi: 10.11613/BM.2021.010502. Epub 2020 Dec 15. PMID: 33380887; PMCID: PMC7745163.
4. Button KS, Ioannidis JP, Mokrysz C, Nosek BA, Flint J, Robinson ES, Munafò MR. Power failure: why small sample size undermines the reliability of neuroscience. Nat Rev Neurosci. 2013 May;14(5):365-76. doi: 10.1038/nrn3475. Epub 2013 Apr 10. Erratum in: Nat Rev Neurosci. 2013 Jun;14(6):451. PMID: 23571845.
5. Moher D, Dulberg CS, Wells GA. Statistical power, sample size, and their reporting in randomized controlled trials. JAMA. 1994 Jul 13;272(2):122-4. PMID: 8015121.
6. Charles P, Giraudeau B, Dechartres A, Baron G, Ravaud P. Reporting of sample size calculation in randomised controlled trials: review. BMJ. 2009 May 12;338:b1732. doi: 10.1136/bmj.b1732. PMID: 19435763; PMCID: PMC2680945.
7. Schulz KF, Altman DG, Moher D; CONSORT Group. CONSORT 2010 statement: updated guidelines for reporting parallel group randomised trials. BMJ. 2010 Mar 23;340:c332. doi: 10.1136/bmj.c332. PMID: 20332509; PMCID: PMC2844940.
8. Harden M, Friede T. Sample size calculation in multi-centre clinical trials. BMC Med Res Methodol. 2018 Nov 29;18(1):156. doi: 10.1186/s12874-018-0602-y. PMID: 30497390; PMCID: PMC6267841.
9. Tulka S, Knippschild S, Funck S, Goetjes I, Uluk Y, Baulig C. Reporting of statistical sample size calculations in publications of trials on age-related macular degeneration, glaucoma and cataract. PLoS One. 2021 Jun 4;16(6):e0252640. doi: 10.1371/journal.pone.0252640. PMID: 34086796; PMCID: PMC8177464.
10. Iheozor-Ejiofor, Z., Lakunina, S., Gordon, M., Akintelure, D., Sinopoulou, V. and Akobeng, A. (2021), Sample-size estimation is not reported in 24% of randomised controlled trials of inflammatory bowel disease: A systematic review. United European Gastroenterol J, 9: 47-53. https://doi.org/10.1177/2050640620967899
11. Cornish R. Statistics: an introduction to sample size calculations. Loughborough: Mathematics Learning Support Centre; 2006.
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Publication history

Received: 13/06/2023

Accepted: 15/06/2023

Online First: 27/06/2023

Published: 26/07/2023

Article Online First time: 14 days

Article editing time: 43 days


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